TP53 and ovarian carcinoma: In particular, the apoptotic protein Bad—which can block anti-apoptotic proteins Bcl-xL, Bcl-2, and Bcl-W [13, 14]—has been tested in several ovarian cancer cell lines and shows greatly enhanced apoptotic activity compared to wt p53 when fused to p53 (Fig. 2) (unpublished data, submitted for review).