Interestingly, the relative expression levels of − 279/+ 5, Ran, and Brms1 differed between the three ovarian cancer cell lines, with Brms1 showing clear superiority in Kuramochi cells (Fig. 7c), Ran and Brms1 significantly outstripping − 279/+ 5 in Skov3 cells (Fig. 7a), and a relatively close race between − 279/+ 5 and Brms1 in Ovcar3 cells (Fig. 7b). The gene discussed is RAN; the disease is ovarian carcinoma.