Considering established driver mutations included in the Cancer Gene Census ( [61]; https://cancer.sanger.ac.uk/census), we observed respective Varns in most of the HCCs (n = 9; 1–3 Varns per patient), foremost the previously mentioned gene CTNNB1 (n = 8) but also the androgen receptor, mediator complex subunit 12 (MED12), nuclear receptor corepressor 1 (NCOR1), neurogenic locus notch homolog protein 1 (NOTCH1) (all n = 2), and NOTCH2/PIK3CA (n = 1). Here, NOTCH1 is linked to cancer.