TNF and Arthralgia: Here, we detected that female gender, older age at diagnosis, a longer disease duration, IBD-related surgery not due to fistula or abscesses, 5-ASA treatment, treatment with steroids, treatment with anti-TNF as well as the presence of other EIM were independently associated with the occurrence of arthritis/arthralgia in the CD patients of the SIBDCS patient collective (Table 4).