In addition, the myelocytomatosis oncogene cellular homolog (Myc) proto-oncogene is thought to be regulated by BMAL1/neuronal PAS domain protein 2 (NPAS2) (a CLOCK paralogue) action on its E-boxes, which may contribute to enhanced tumor growth in Per2 mutant mice in response to DNA damage [76]. This evidence concerns the gene NPAS2 and neoplasm.