Overall expression of oncogenic retinoic acid syndrome (RAS) signaling factors as well as receptors and ligands of several growth factor signaling pathways (epidermal growth factor [EGF]/fibroblast growth factor [FGF]/vascular endothelial growth factor [VEGF]), which contribute to cancer progression, was also induced in response to CCD (Fig 2F–2I; S5, S6, S7 and S8 Tables). This evidence concerns the gene EGF and cancer.