RB1 and cancer: One of the primary ocular tumors that is malignant is retinoblastoma, which affects the developing retina and is set off by mutations in the retinoblastoma (RB1) gene, usually occurring during childhood1, 2 It is well known that tumorigenesis of several cancers including RB happens chiefly due to oncogene hyperactivation and tumor‐suppressor gene inactivation.3 Therefore, exploring the molecular mechanism in the occurrence and progress of RB is important for finding a new and effective treatment for this disease.