PKD1 and kidney failure: Indeed, Axin2, Cd44, Ccnd1 (Figure 6A,B) and to certain extent Myc (see supplementary material, Figure S4), showed significantly lower expression in double KO compared with Pkd1 KO mice, both at 10 weeks after DCVC and at kidney failure, suggesting a reduced activation of the canonical Wnt signalling in the absence of Fjx1.