We also studied the expression of key genes of several pathways known to be involved in renal fibrosis, such as Notch 28, 29, Hedgehog 30, 31, Wnt 32, 33, hypoxia 34, 35, 36, 37, 38 and Egf 39, 40, 41. The gene discussed is EGF; the disease is renal fibrosis.