When we analysed fibrogenesis at 10 weeks after DCVC and kidney failure, expression of alpha‐1 type I collagen (Col1a1) and Vimentin (Vim) was significantly reduced in the double KO compared to Pkd1 KO at 10 weeks after DCVC, both at the mRNA (Figure 4C,D) and protein levels (Figure 5A,B); expression of Fibronectin (Fn1) showed a similar trend (Figure 4C,D). This evidence concerns the gene PKD1 and kidney failure.