MMP9 and intrahepatic cholangiocarcinoma: Their study also found that although MMP-9 overexpression was not associated with patient clinicopathological parameters, overall survival was significantly lower in patients with high MMP-9 expression than in patients with negative or low MMP-9 expression, suggesting that the expression of MMP-9 in tissues is of great significance in the evaluation of postoperative prognosis of intrahepatic cholangiocarcinoma.