One important methodological note, for future work, is that our exploratory analysis, in which we combined the connectivity maps from different frequency bands using a vector sum approach, revealed both more robust connectivity patterns across participants, with increased number of valid edge connections, and increased sensitivity to both APOE-ɛ4 carrier effects and Alzheimer disease-related changes in connectivity. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.