APOE and Alzheimer disease: Here, we compared our finding of a spatially-localised increase in functional brain connectivity in young APOE-ɛ4 carriers to connectivity changes in a cohort of AD patients, in which we have recently reported strongly decreased alpha and beta-band oscillatory network activity in parieto-temporal areas with MEG (Koelewijn et al., 2017), for AD patients compared to age-matched controls.