ROCK1 and cancer: ROCK1/LIMK1/COFILIN1 pathway has been a well‐understood signal pathway which is reported to regulate actin cytoskeletal dynamics, and thus influences the survival and metastasis of cancer cells.27, 28 LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin‐binding factor cofilin (CFL), which is the only known substrate of LIMK at the present.