ROCK1/LIMK1/COFILIN1 pathway has been a well‐understood signal pathway which is reported to regulate actin cytoskeletal dynamics, and thus influences the survival and metastasis of cancer cells.27, 28 LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin‐binding factor cofilin (CFL), which is the only known substrate of LIMK at the present. This evidence concerns the gene MARK2 and cancer.