The expression of GDF11 was shown to decrease in the skeletal muscle of obese mice.2 Meanwhile, in women older than 60, GDF11 was reported to be negatively correlated with body mass, body mass index and fat mass.3 In addition, GDF11 levels were found to be higher in 12‐to 16‐year‐old girls with anorexia nervosa, which is characterized by low body mass.4 However, its effects on mesenchymal stem cell and pre‐adipocyte adipogenic differentiation and its underlying mechanism remain ambiguous. This evidence concerns the gene GDF11 and anorexia nervosa.