MAPT and Alzheimer disease: H-AD injection resulted in a 12-fold increase in tau phosphorylation in the ipsilateral CA1 (Supplementary Fig. 5B and D, P < 0.0001) and a 5-fold increase in the contralateral side (Supplementary Fig. 5D, P = 0.0003) compared to animals injected with PBS (Supplementary Fig. 5C and D).