The membrane localization of c‐Raf can be activated by the EGFR/Ras signalling pathway, resulting in the malignant transformation of human epithelial cells.14 Therefore, we proposed that the overexpression FAM83D might promote the migration and proliferation of cancer cells through activates the EGFR and c‐Raf signalling pathways. Here, SACK1D is linked to cancer.