SACK1D and liver cancer: FAM83D gain of function activated the PI3K/mTOR signalling pathway and resulted in cell division in breast cancer.24 Dong et al investigated the role of FAM83D in liver cancer, showing that FAM83D contributes to the proliferation of cancer cell and colony formation through activation of the MEK/ERK pathway.26 In this study, using the isogenic cell model, we suggested that high expression of FAM83D significantly promotes proliferation, migration and spheroid formation in ovarian cancer cells (Figures 2 and 3).