For example, lncRNA HAND2‐AS1 could maintain the stemness of non‐small cell lung cancer cells 6; a novel lncRNA, ZNF281, inhibits the self‐renewal capacity of glioma stem‐like cells via regulating the nuclear factor‐κB1 signaling pathway 7; and lncRNA UCA1 enhances the stemness of glioma cells by acting as a competitive endogenous RNA (ceRNA) for Slug 8. The gene discussed is ZNF281; the disease is central nervous system cancer.