HCV-JFH1 infection redistributes several SG components, including G3BP1, ataxin-2 (ATX2), and poly(A)-binding protein 1 (PABP1), to the HCV replication complex (RC) (Ariumi et al.2011; Pene et al.2015), and co-opts G3BP1 to mediate efficient viral replication by interaction with NS5B and the 5′ end of the HCV minus-strand RNA (Ariumi et al.2011; Garaigorta et al.2012). Here, G3BP1 is linked to infection.