Thanks to previously established local age-dependent reference limits for striatal VOIs uptake, AIs and C/P ratio [28], we also confirmed that CBS subjects have a relative preservation of presynaptic dopamine transporters as they exhibited higher P uptake in comparison to PD (p < 0.005) and higher P, C and S uptake compared to MSA-P (p < 0.0005) and PSP (p < 0.001). The gene discussed is SLC6A3; the disease is multiple system atrophy.