It is also important to mention, as an alternative, non-invasive strategy, a nutritional therapy with extra virgin olive oil increases HO-1 and Nrf-2 protein expression in animal models of SLE and diminishes activation of JAK/STAT, MAPK, and NF-kB pathways that can drive proinflammatory cytokine and chemokine production from many immune cell types (55). Here, HMOX1 is linked to systemic lupus erythematosus.