SOD1 misfolding has been reported in all ALS sub-types, including the non-SOD1-linked familial and sporadic cases (Shibata et al., 1994) and several studies propose that misfolded protein can be both secreted and taken up by the extracellular environment through exosomes (Gomes et al., 2007; Nonaka et al., 2013; Grad et al., 2014; Iguchi et al., 2016; Pinto et al., 2017). This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.