CTRL and amyotrophic lateral sclerosis: LMVs of all patients analyzed were enriched with misfolded SOD1 and densitometric analysis of this protein, normalized against CD45, revealed a slight increase of this protein in ALS patients compared to controls (0.8431 ± 0.1236 for CTRL and 1.008 ± 0.1274 for ALS) (Figure 3B).