Next, adding a minimal GRS consisting of five major genetic AMD variants in CFH (rs10922109 and rs570618), CFB (rs116503776), ARMS2/HTRA1 (rs3750846) and C3 (rs2230199), (model C) produced also a significantly better predicting performance compared to model A (Nagelkerke R2 0.48; AIC 258.0). The gene discussed is C3; the disease is age-related macular degeneration.