The first CAV3 mutation associated with muscle disorders was described 20 years ago and today it has been extended to five distinct genetic disorders: rippling muscle disease (RMD), distal myopathies (DM), hyperCKemia (HCK), limb-girdle muscular dystrophy 1C (LGMD-1C), and familial hypertrophic cardiomyopathy (HCM)20,39. Here, CAV3 is linked to hypertrophic cardiomyopathy.