To confirm the expression and location of TNC in CRC tissues, we detected the expression of TNC using immunohistochemistry in 30 cases of non-neoplastic colonic mucosa (NCM), 30 cases of adenomatous colorectal polyps (AD), 30 cases of colorectal carcinoma in situ (CIS) and 50 cases of invasive colorectal carcinoma (ICC). Here, TNC is linked to Alzheimer disease.