Comparative qPCR and immunohistochemical analysis of LUAD tumor sections 21 weeks after infection of KP mice confirmed significant Nf1 mRNA downregulation (Fig 1G), p‐Fak1 protein upregulation (Fig 1H–J), and Psat1 mRNA upregulation (Fig 1K and L) in sgNf1‐infected mice, with the most profound effects observed in the sgNf1.3‐infected group. The gene discussed is PTK2; the disease is neoplasm.