AREG and neoplasm: As expected, overexpression of WT Nf1 in KPΔNF1 cells downregulates Fak1 (Appendix Fig S6G), downregulates its target genes Psat1, Areg, and Peg10 (Appendix Fig S6H–J), retards tumor growth (Appendix Fig S6K), and rescues cytotoxicity induced by CB‐839 or AOA (Appendix Fig S6L and M).