However, in breast cancer cells with amplified serine biosynthesis, Psat1 contributes a significant fraction of glutamine‐derived carbon flux to α‐KG, indicating that Psat1 can play an important role in Krebs cycle anaplerosis of glutamine‐derived carbon in cancer cells (Possemato et al, 2011). The gene discussed is PSAT1; the disease is breast carcinoma.