BMPR1A and neoplasm: The expression of Bmpr1a was significantly decreased in the resulting tumor organoids (Figure 5—figure supplement 1B), and transplantation of Bmpr1a knock-down tumor organoids in the presence of 5’-azacitidine gave rise to secondary tumors with decreased expression of luminal markers with squamous differentiation compared to tumor organoids with intact Bmpr1a (Figure 5B,C and Figure 5—figure supplement 1C,E).