PDX1 and familial pancreatic carcinoma: Spontaneous tumors that arise in the KRasG12D/+, Trp53R172H/+, pdx-1-Cre (KPC) genetically engineered mouse model of PDA mirror human pancreatic cancer with elevated levels of immune suppressive macrophages and myeloid-derived suppressor cells, with concomitant decreased numbers of infiltrating T cells [17, 18, 47].