CD8A and pancreatic neoplasm: The proliferation and activation of functional orthotopic tumor-infiltrating CD8+ T cells was monitored by staining with Ki-67 and granzyme B. Much as we observed in subcutaneous tumors, there was a significant increase in granzyme B+ and Ki-67+ CD8+ T cells within the orthotopic pancreatic tumors after DMXAA treatment (Fig. 3f).