Within the remaining 145 IDH1 wildtype glioblastoma patients, the difference in PFS between PIK3CA mutant and PIK3CA wildtype tumors was statistically significant by Wilcoxon test (p = 0.02) and was a trend to significance by log-rank test (p = 0.11) (Additional file 3: Figure S3). This evidence concerns the gene IDH1 and glioblastoma.