RAD50 and infection: We observed that Delta-24-RGD infection resulted in the inhibition of cellular machinery, involving Rad50 and Mre11 proteins; both proteins are part of the MRN complex [21, 33] which is involved in the repair of double strand breaks (DSB) (Fig. 2a and Additional file 1: Figure S3A); Rad 51 is also inhibited, a protein with a major role in the homologous recombination repair (HRR [13, 27]).