CD4 and diffuse intrinsic pontine glioma: Evaluation of pro-inflammatory cytokines expression levels, such as Granzyme B (P = 0.19) and IFNg (P = 0.13), in addition to CD4 (P = 0.57) and CD8a (P = 0.16) expression levels, presented an increased trend in tumors treated with Delta-24-RGD and irradiation compared with single treatments (Fig. 3g), indicating that the combination stimulates the immune response in DIPG tumors.