Indeed, we observed that KDM8 expression was negatively correlated with the expression levels of canonical cell cycle genes: cyclins (CCNA2, CCNB1, CCNB2, CCND1, CCNE1, and CCNE2) and cyclin-dependent kinases (CDK1, CDK2, CDK4, CDK6, CDK7, and CDK8), which were consistent across all liver and pancreatic cancer cohorts (Fig. 5d). This evidence concerns the gene CDK4 and pancreatic neoplasm.