Pathway analysis of KDM8 DEGs revealed enrichment of processes related to cell adhesion, suggesting potential crosstalk between KDM8 and HNF4A. Of the 745 DEGs, analysis on a hepatoma-based HNF4A chromatin immunoprecipitation-sequencing dataset demonstrated that 148 genes were directly bound by HNF4A [37]. This evidence concerns the gene KDM8 and hepatocellular carcinoma.