Indeed, we observed that KDM8 expression was negatively correlated with the expression levels of canonical cell cycle genes: cyclins (CCNA2, CCNB1, CCNB2, CCND1, CCNE1, and CCNE2) and cyclin-dependent kinases (CDK1, CDK2, CDK4, CDK6, CDK7, and CDK8), which were consistent across all liver and pancreatic cancer cohorts (Fig. 5d). This evidence concerns the gene CCNE1 and familial pancreatic carcinoma.