In contrast to IFN-β, exposure of Ep/non-CSC to certain tumor-associated cytokines (such as OSM or TGF-β) can reprogram the cells to a CSC state (with the expression of CSC genes and associated biological activities, including tumor-initiating capacity, invasiveness, and resistance to chemotherapy) [2, 3, 16]. This evidence concerns the gene IFNB1 and neoplasm.