AKT1 and rheumatoid arthritis: Sixty-one pathways were significantly affected by upregulated genes (p < 0.05) in the cortex, including metabolic pathway, olfactory transduction, calcium signaling pathway, pathways in cancer, glutamatergic synapse, phototransduction, rheumatoid arthritis, PI3K-Akt signaling pathway, MAPK signalling pathway, natural killer cell mediated cytotoxicity, vascular smooth muscle contraction, cytokine-cytokine receptor interaction, serotonergic synapse, morphine addiction etc.(Fig. 4e).