Slavin et al. identified deleterious BARD1 variants in 7 of 2134 BRCA1/2-negative familial BC patients (carrier frequency = 0.33%) and reported BARD1 as a moderate-risk BC predisposition gene with an odds ratio (OR) of 3.18 (95% confidence interval [CI] = 1.34–7.36; P = 0.012) [6]. This evidence concerns the gene BRCA1 and breast cancer.