In the subgroup of 3651 index patients with BC and without an OC family history (mean AAD 48.3 years; range 19–91 years), 19 patients carried heterozygous germline LoF variants in BARD1, resulting in a carrier frequency of 0.52% and an OR of 5.41 (95% CI = 3.10–9.44; P < 0.00001) compared with all control individuals (Table 1). Here, BARD1 is linked to breast cancer.