When comparing clinical characteristics of study participants in relation to the circulating copeptin levels, we observed that patients belonging to the highest copeptin quartile had a higher prevalence of male sex, MS, NAFLD and NASH and greater waist circumference, serum creatinine, and uric acid than those belonging to the lowest quartile (Table 3). The gene discussed is AVP; the disease is metabolic dysfunction-associated steatotic liver disease.