SOD1 and metabolic dysfunction-associated steatohepatitis: We also showed in this study that the Alisma and Rhizoma decoction significantly accentuated the rise in intrahepatocellular SOD activities and suppressed MCD-induced increase in intrahepatocellular MDA contents, suggesting that the Alisma and Rhizoma decoction may alleviate NASH by inhibiting oxidative stress in the liver.