miRNA-140-5p expression was downregulated in Wilms’ tumor tissues, and miR-140-5p could regulate Wilms’ tumor progression via the IGF-1R/ AKT and TGFBRI/SMAD2/3 pathways and that it might have tumor suppressive functions with regard to Wilms’ tumor progression and metastasis. This evidence concerns the gene SMAD2 and Nephroblastoma.