The confounding factors that are difficult to exclude in patients with OSA, such as age, BMI, and body fat mass, have been shown to play a role in many inflammatory markers previously shown to be associated with OSA.A recent metaanalysis has shown that increases in inflammatory marker levels (including CRP, TNFa, IL-6, IL-8, ICAMs, VCAMs, and selectins) in OSA patients positively influenced the severity of the disease. This evidence concerns the gene TNF and obstructive sleep apnea syndrome.