In contrast, weak affinity was detected between PSS and VEGF165 (Supplementary Table S1), while the KD of heparin was 8.09 × 10−7 M. As FGF2 is a crucial growth factor to regulate angiogenesis and the function of tumor cells, these data indicate that FGF2 was probably a potential target for PSS to improve tumor environment. This evidence concerns the gene FGF2 and neoplasm.