Recently, we reported PLK4 overexpression in pediatric embryonal tumors including peripheral malignant rhabdoid tumors (RT), atypical teratoid rhabdoid tumors (AT/RT) of the brain, medulloblastomas (MB), and neuroblastoma of the CNS (CNS-NB) [36,37,38,39]. The gene discussed is PLK4; the disease is neuroblastoma.