CNR1 and fatty liver disease: Hepatic CB1R activation stimulates lipogenesis transcription factor and sterol-regulatory element-binding transcription factor 1c (SREBP1c) and increases accumulation of TGs via up-regulation of its downstream lipogenesis genes, including fatty acid synthase (FAS), stearoyl-coenzyme A (CoA) desaturase 1 (SCD1), and acetyl-CoA carboxylase (ACC), thus leading to hepatic steatosis.