Several chemokines (CCL2, CCL5, CXCL1, CXCL10 and CXCL12) produced by tumour and stromal cells activate their specific mast cell receptors (CCR2, CCR3, CXCR2, CXCR3 and CXCR4), which are important for TAMC localization in TME [49,79,110,111,112,113,114,115,116]. The gene discussed is CXCR4; the disease is neoplasm.