Specific T-cell responses have been demonstrated by direct ex vivo tetramer analysis and/or following in vitro antigenic restimulation experiments towards the following AML-related tumor antigens: WT1 [33,35,36,39,44,51,52,53,58,59], PRAME [44,48,53,59], hTERT [39,60,61], and MUC1 [59]. The gene discussed is PRAME; the disease is acute myeloid leukemia.