Knocking down LDHA enhances the cytochrome c release (the amount released is 5.38 ± 0.71 ng·mL−1 at 48 h LDHA shRNA Lenti treatment of hepatocellular carcinoma cells) from the mitochondria to the cytoplasm, providing a key signal initiating the irreversible death sequence [70,72,75]. This evidence concerns the gene LDHA and hepatocellular carcinoma.