ANXA5 and melanoma: In a panel of malignant human melanoma cells low micromolar concentrations of PMS (≤ 10 μM, 24 h) displayed pronounced apoptogenicity as detected by annexin V-FITC/propidium iodide flow cytometry and immunodetection of PARP-1 cleavage; PMS-induced cell death was suppressed by antioxidant or pan-caspase inhibitor co-treatment (Figure 2 and Figure 6).