Various classes of therapeutic pro-oxidants (e.g., organic endoperoxides and Michael-type electrophiles, antagonists of glutathione and thioredoxin metabolism, MnSOD-mimetics, Nrf2 antagonists, and inducers of ferroptosis) have been examined as promising experimental cancer therapeutics [7,20,23,24,25,26]. The gene discussed is SOD2; the disease is cancer.