Gene expression array analysis in A375 melanoma cells (PMS, 10 μM; 6 h) revealed transcriptional upregulation of heat shock (HSPA6, HSPA1A), oxidative (HMOX1), and genotoxic (EGR1, GADD45A) stress responses, confirmed by immunoblot detection that included redox regulators (NRF2, HO-1, EGR1, HSP70) and modulation of pro-apoptotic (BAX, PUMA) as well as anti-apoptotic factors (Bcl-2, Mcl-1) (Figure 3). The gene discussed is BBC3; the disease is melanoma.