PTH and Marchiafava-Bignami disease: The Kidney Disease Improving Global Outcomes (KDIGO) group defines CKD-MBD as a systemic disorder of mineral and bone metabolism caused by CKD and manifested by one or a combination of the following: (1) abnormalities of calcium, phosphorous, PTH, or vitamin D metabolism; (2) abnormalities in bone turnover, mineralization, volume, linear growth, or strength; or (3) vascular or other soft-tissue calcification [30,51].