Regarding the EPA anti-lipolytic effect, Du et al. (2015) observed similar effects in the S180 ascitic cancer model after treatment with EPA derived from the starfish, Asterias amurensis, which was due to a reduction of ZAG, adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), and mitochondrial uncoupling protein 2 (UCP-2) expressions [115]. This evidence concerns the gene PNPLA2 and cancer.