Concerning the effects of resolution mediators on depression, RvE1 and RvE2 intracerebroventricular (i.c.v.)administration significantly decreased lipopolysaccharide (LPS)-associated depressive behavior via the activation of the resolvin receptor ChemR23 according to the assessment of LPS-induced depression in a mouse model [47]. The gene discussed is CMKLR1; the disease is major depressive disorder.