NFE2L2 and obesity due to melanocortin 4 receptor deficiency: Moreover, resveratrol activates the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway-mediated antioxidant enzyme expression and alleviates the inflammation by protecting against oxidative damage and T-lymphocyte subset-related chronic inflammatory response in the development of HFD-induced obesity [106] (Figure 1).