In 2015, Jiang [50] developed a nano-carrier encapsulating Crizotinib (approved for EML4-ALK fusion positive lung cancer) within polylactide tocopheryl polyethylene glycol 1000 succinate (PLA-TPGS), which showed a sustained release, induced remarkable cytotoxicity in NCIH3122 lung cancer cells, and noticeable early and late apoptosis. The gene discussed is ALK; the disease is lung cancer.