ESR1 and breast carcinoma: However, univariate analysis within subgroups showed that shorter disease-free survival was associated with LPA positivity (p = 0.005) and stromal LPA3 negativity (p = 0.015) in breast cancer with adipose stoma and ER negative cases, and LPA3 positivity (p = 0.007) was associated with shorter overall survival (Figure 3).