Diabetes-related hyperglycaemia and hyperlipidaemia have been shown to upregulate P2rx7 expression or activity in skin fibroblasts in patients [15], while this receptor is also increased in the pancreatic α-cells [16], macrophages [16], kidneys [17], and corneas [18] of mice with streptozotocin (STZ)-induced diabetes. The gene discussed is P2RX7; the disease is diabetes mellitus.