Overexpression of α5 nAChR subunit in non-small cell lung cancer (NSCLC) is associated with proliferation, migration, and invasion of cancer cells through ERK1/2 and PI3K/Akt signaling pathways, and silencing this subunit can inhibit the progress of nicotine-related NSCLC [37,38,39]. This evidence concerns the gene AKT1 and cancer.