EPAS1 and hereditary pheochromocytoma-paraganglioma: All three groups (EPAS1/HIF2α vs. cluster 1 vs. cluster 2) showed a similar TH expression independent of HIF2α expression (Figure 6C), which is in accordance with our in vitro findings using mouse pheochromocytoma cells expressing Hif2α (Figure 4A,E).