TERF1 and idiopathic aplastic anemia: To address these problems of aplastic anemia associated with telomere shortening, Bar et al. utilized TERT-expressing AAV9 in two different aplastic anemia-suffering TG mouse models (partial deletion of the TRF1 gene in BM by the CreLox system or constitutive silencing of TERT in TERT−/− to induce telomere shortening) [55].