Treatment of oral squamous cell carcinoma (OSCC) cells with adenovirus expressing TERC-targeted shRNA (Ad-shTERC) led to a time-dependent increase in the inhibition of TERC mRNA expression up to 3 days post treatment, and adenovirus expressing TERT-targeted shRNA (Ad-shTERT) similarly inhibited TERT mRNA expression [77]. The gene discussed is TERT; the disease is oral cavity squamous cell carcinoma.