Notably, mTERT promoter-driven oncolytic adenovirus induced complete regression in 40% of mice by 10 days after virus injection, and no palpable tumor was observed for up to 2 months, showing more potent and durable tumor growth inhibition than those achieved by the other human TERT-driven oncolytic adenoviruses reported in 2003. This evidence concerns the gene TERT and neoplasm.