TP53 and cervical carcinoma: Such discord between p53 restoration and the subsequent induction of apoptosis in metastatic cervical carcinoma-derived HPV16 cell lines has also been discussed in the context of E6 suppression by siRNA [21], leading us as well as others [88] to question whether decades of in vitro culture have introduced subsequent mutations in apoptotic pathways which reduce reliance on continuous oncogene expression.